EC C.7

OECD 111

OPPTS/OCSPP835.212

Hydrolysis as a function of pH

Study description:

This Guideline is designed as a tiered approach; each tier is triggered by the results of the previous tier. Sterile aqueous buffer solutions of different pH values (pH 4, 7 and 9) are treated with the non-labelled or labelled test substance (only one concentration, which should not exceed 0.01 M or half of the saturation concentration). They are incubated in the dark under controlled laboratory conditions (at constant temperatures). After appropriate time intervals, buffer solutions are analysed for the test substance and for hydrolysis products. The preliminary test should be carried out for 5 days at 50 ¬± 0.5ºC and pH 4.0, 7.0 and 9.0. The second tier consists of the hydrolysis of unstable substances, and the third tier is the identification of hydrolysis products. The higher Tier tests should be conducted until 90 % hydrolysis of the test substance is observed or for 30 days whichever comes first.

Request more information:

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Tips: search our services here by using keywords, species, guideline number or endpoint.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
You can also filter by sector using the buttons below.

SANTE 2020/12830 Rev.2.

14th February 2023.

Sector:
Analytical Chemistry
Read more & request a quote
ISO14669

Crustacean Acute: Toxicity Study - Acartia Tonsa or Tisbe battaglia. Determination of acute lethal toxicity to marine copepods.

Sector:
Ecotoxicology
Read more & request a quote

Corophium volutator acute toxicity

Sector:
Ecotoxicology
Read more & request a quote

Corophium volutator chronic study

Sector:
Ecotoxicology
Read more & request a quote

Method Development

Sector:
Analytical Chemistry
Read more & request a quote

Arenicola marina sediment study

Sector:
Ecotoxicology
Read more & request a quote
OPPTS/OCSPP850.1035

Mysid Acute (Static and Flow Through)

Sector:
Ecotoxicology
Read more & request a quote
OPPTS/OCSPP850.1055
ISO17244

Oyster Embryo Larval Development Test

Sector:
Mixed
Read more & request a quote
OPPTS/OCSPP850.135

Mysid Chronic Toxicity Test

Sector:
Mixed
Read more & request a quote
OPPTS/OCSPP850.14

Fish: Chronic: Saltwater - Toxicity Study

Sector:
Ecotoxicology
Read more & request a quote
OPPTS/OCSPP850.45
ISO10253

Algal Acute Marine - Analytical Chemistry

Sector:
Analytical Chemistry
Read more & request a quote
OPPTS/OCSPP850.45
ISO10253

Algal Acute Marine - Growth Inhibition Study

Sector:
Ecotoxicology
Read more & request a quote
OECD 102

Melting Point/Melting Range

Sector:
Analytical Chemistry
Read more & request a quote
OECD 103

Boiling Point

Sector:
Analytical Chemistry
Read more & request a quote
OECD 104

Vapour/Pressure (isoteniscope)

Sector:
Analytical Chemistry
Read more & request a quote
OECD 105
EC A.6

Water Solubility

Sector:
Analytical Chemistry
Read more & request a quote
OECD 106

Adsorption/Desorption

Sector:
Analytical Chemistry
Read more & request a quote
OECD 107
OPPTS/OCSPP830.755
EC A.8

Partition Coefficient

Sector:
Analytical Chemistry
Read more & request a quote
OECD 109
EC A.3

Relative Density

Sector:
Analytical Chemistry
Read more & request a quote
OECD 111
OPPTS/OCSPP835.212
EC C.7

Hydrolysis as a function of pH

Sector:
Analytical Chemistry
Read more & request a quote