The melting point is defined as the temperature at which the phase transition from the solid to the liquid state at atmospheric pressure takes place. It is considerably affected by impurities. The selection of a particular method depends mainly on the state of physical aggregation of the sample and on whether or not the substance can be pulverized easily, with difficulty, or not at all. The methods are: the capillary/liquid bath, the capillary/metal block, the Kofler hot bar, the melt microscope, the differential thermal analysis and differential scanning calorimetry, the freezing temperature and the pour point.
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SANTE 2020/12830 Rev.1.
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Hydrolysis as a function of pH