Understanding Endocrine Disruptor Studies
In the realm of environmental risk assessment, evaluating the potential impacts on endocrine systems is of increasing importance, and encompasses a range of assays, from in vitro screenings to complex in vivo studies, all designed to address endocrine activity and adversity.
These assays are in line with the OECD conceptual framework (OECD GD 150), forming a crucial part of the endocrine disruptor testing strategy as per the guidance provided by ECHA/EFSA and the Endocrine Disruptor Screening Program (EDSP) Tier 1 screening battery.
Levels of Endocrine Disruption Testing
The assessment of endocrine disruption entails several levels of testing:
1. Level 1 Testing: This involves a comprehensive review of existing data coupled with in silico modelling.
2. Level 2 Testing: This comprises a battery of in vitro assays designed to delve deeper into potential endocrine disruption.
3. Levels 3, 4, and 5 Testing: These encompass in vivo assays conducted in either mammalian or non-mammalian test systems, providing a holistic understanding of the chemical's impact on endocrine systems.
Our team of experts are at your disposal to design and conduct the necessary testing and procedures, adhering to international guidelines within a GLP (Good Laboratory Practice) environment.
Our study portfolio of GLP endocrine disruptor assays, are designed to meet the highest industry standards. Additionally, many of these study designs can be conducted as non-GLP, rapid-screening alternatives.
Regulatory Updates
As of 2018, both EFSA (Plant Protection Products) and ECHA (Biocides) have introduced criteria for endocrine disruption in their regulations. This mandates a thorough investigation of EATS-mediated (Estrogen, Androgen, Thyroid, Steroidogenesis) adversity.
Endocrine disruptor studies play a pivotal role in ensuring the safety and well-being of both humans and the environment. With our study portfolio and expert guidance, you can navigate this critical aspect of environmental risk assessment with both confidence and compliance.
